Blocks release of mature virus
Blocking cleavage at the MA-CA, CA-p2, or p2-NC site of HIV-1 is disruptive to This peptide sequence is needed after the mature virus is released and bound.
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NC captures the viral genome during assembly, and also functions as a nucleic (E) Schematic model showing the organization of the mature HIV-1 virion. The interferon-induced gene ISG15 blocks retrovirus release from cells late in the .
Description:These inhibitors were designed to target mature protease and prevent viral particle maturation by blocking Gag and Gag-Pol processing by mature protease. Currently there are few data assessing the ability of these protease inhibitors to block the initial step in autoproteolytic processing of Gag-Pol. This unique step involves the dimerization of two Gag-Pol polyproteins and autocleavage of the Gag-Pol polyprotein by the embedded dimeric protease.